The Institute of Medicine recommends against doses averaging above 4,000 IU/day in unsupervised patients. Studies to assess the long-term safety of levels from 80 to 150 ng/ml are lacking. ![]() Toxicity from short-term exposure requires levels near or above 150 ng/ml. Primitive sun-exposed populations have 25(OH)D levels predominantly in the 40-60 ng/ml range. There is decent evidence for suboptimal calcium absorption with levels below 32 ng/ml. Good evidence exists for a risk of overt bone disease (osteomalacia, Rickets) with levels below 20 ng/ml. It is generally recognized that the minimal blood level needed to prevent overt bone disease is 20 ng/ml. The ideal range is generally between 30 and 60ng/ml of 25(OH) cholecalciferol. These recommendations apply only to Maximum D3®. ![]() Then reassess 25 (OH)D levels after 12 weeks.Serum 25(OH)D 20 ng/ml: 2 capsules weekly.The most common regimen for loading and initial follow up with Maximum D3®:
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